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Research on Brahmi ....

Several Brahmi researches have been done in India regarding Brahmi and its contraceptive effects.

  1. Indian Journal of Pharmacology 1997; 29: S359-S365
    NEUROPSYCHOPHARMACOLOGICAL EFFECTS OF THE AYURVEDIC NOOTROPlC BACOPA MONNlERA LINN. (BRAHMI) H.K SINGH. B.N. DHAWAN.
    Central Drug Research Institute, Lucknsw 226 001 India


    The authentication of the traditional claims of Brahmi was initiated by investigating the effect of an alcoholic extract of this plant on acquisition, consolidation and retention of three newlyacquired behavioural responses in albino rats.The chemical constituent responsible for the facilitator effect of brahmi on learning schedules wasidentified as a mixture of two saponins designated as bacosides A and B.

    CONCLUSION: The bacosides significantlyimproved the acquisition, consolidation and retention in the shock-motivated brightness discrimination response.

    More details can be found at : www.shamanshop.net/store/proddetail.cfm/ItemID/35021.0/CategoryID/15500.0/SubCatID/3645.0/file.htm

  2. (a) Anxiety and Depression
    Bacopa's traditional use as an anti-anxiety remedy in Ayurvedic medicine is supported by both animal and clinical research. Research using a rat model of clinical anxiety demonstrated a Bacopa extract of 25-percent bacoside A exerted anxiolytic activity comparable to Lorazepam, a common benzodiazapene anxiolytic drug. But, the Bacopa extract did not induce amnesia, side effects associated with Lorazepam, instead had a memory-enhancing effect.

    (b) Epilepsy
    Although Bacopa has been indicated as a remedy for epilepsy in Ayurvedic medicine, research in animals shows anticonvulsant activity only at high doses over extended periods of time. Early research in India demonstrated that hersaponin (an active constituent) exhibited protection against seizures in mice.

    (c) Bronchitis and Asthma
    Animal studies on rabbit and guinea pig have demonstrated Bacopa extracts to have relaxant effect on chemically-induced bronchoconstriction,probably via inhibition of calcium influx into cell membranes. An in vitro study also demonstrated a methanol extract of Bacopa possessed potent mast cell stabilizing activity comparable to disodium cromoglycate, a commonly used allergy medication. These studies indicate the potential usefulness of Bacopa extracts in bronchoconstrictive and allergic conditions, and warrant human studies.

    (d) Gastrointestinal Disorders
    In vitro, animal, and human studies have demonstrated direct spasmolytic activity on intestinal smooth muscle, via inhibition of calcium influx across cell membrane channels. This property suggests Bacopa extracts may be of benefit in conditions characterized by intestinal spasm such as irritable bowel syndrome (IBS).

    More details and informations at : www.findarticles.com/p/articles/mi_m0FDN/is_1_9/ai_114563492

  3. Bacopa Human Research Update
    Chronic effects of Brahmi (Bacopa monniera) on human memory.
    Roodenrys S. niversity of Wollongong, Woolongong, Australia.Neuropsychopharmacology. 2002 Aug;27(2):279-81.


    A study is reported on the effects of Brahmi (Bacopa monniera) on human memory. Seventy-six adults aged between 40 and 65 years took part in a study in which various memory functions were tested and levels of anxiety measured.
    The results show a significant effect of the Bacopa monniera on a test for the retention of new information.

  4. Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats.
    Phytomedicine. 2002 Apr;9(3):207-11.


    Presently, the standardized methanolic extract of Bacopa monniera; bacoside A was investigated for potential antidepressant activity in rodent models of depression. The effect was compared with the standard antidepressant drug imipramine. After 5 days it was found to have significant antidepressant activity comparable to that of imipramine.

  5. Free radical scavenging capacity and protective effect of Bacopa monniera on DNA damage.
    Phytother Res. 2003 Sep;17(8):870-5.


    In this work, the free radical scavenging capacity of a methanol extract of Bacopa monniera and the effect on DNA cleavage induced by H2O2 UV-photolysis was investigated.

    Conclusion : Bacopa monniera showed a dose-dependent free radical scavenging capacity and a protective effect on DNA cleavage. It has a protective effect on H2O2-induced cytoxicity and DNA damage in human non-immortalized fibroblasts.

    These above informations and more can be obtained from : www.raysahelian.com/bacopa.html

    Other informations and updates on Bacopa research at the following Links :

    www.smart-publications.com/articles/040225bacopa.htm
    www.clarocet.com/referencelibrary/bacopa/

    These findings suggest that bacopa may improve higher order cognitive processes that are critically dependent on the input of information from our environment such as learning and memory.


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